Bouncing, Sticking, Exploding Viruses: Understanding the Surface Chemistry of SARS-CoV-2

Matthew N. Henry

Better understanding of the surface chemistry of the SARS-CoV-2 virus is needed to
reduce transmission and accelerate vaccine design.

Researchers at Michigan Tech, TÜV SÜD UK National Engineering Laboratory and University of Edinburgh call for increased research on virus surface stability
and interaction in “Surface Chemistry Can Unlock Drivers of Surface Stability of SARS-CoV-2 in Variety
of Environmental Conditions
” in the Cell Press journal Chem. They highlight the need to understand the different environmental conditions that
affect the surface chemistry of viruses like SARS-CoV-2, the virus that causes the
disease COVID-19.

Creating an Unfriendly Surface for Viruses

We’re told to wash our hands with soap for 20 seconds to kill viruses. Why? Because
the soap interacts with the surface chemistry of a virus, particularly the lipid,
or fatty, casing around it, and essentially makes the virus explode.

Handwashing is a clear example of why understanding how viruses interact with surface
environments is important. Increased research will better equip us to diminish how
long viruses survive on surfaces or in the air, an important way to stop the spread. 

Play Virus Surface Chemistry and COVID-19 video

Preview image for Virus Surface Chemistry and COVID-19 video

Virus Surface Chemistry and COVID-19

Research by Michigan Tech’s Health Research Institute seeks to understand the surface
chemistry of viruses and how its interactions with surfaces — stainless steel, copper,
plastic, cardboard — can increase the virus’s viability or kill the virus particles.

“If the surface is not friendly, it’s easier for the virus to fall apart. Where the
virus has more friendly interactions with the surface, it’s more likely to stay infectious,”
said Caryn Heldt, professor of chemical engineering and director of the Health Research Institute at Michigan Technological University.

About the Researcher 


“Viruses have unique ways of interacting with surfaces. The surface chemistry of the
virus will change how the virus interacts with water,” Heldt said. “If water such
as humidity, which is common in your breath and in the air, gets between the virus
and a surface, it can really change the way the virus interacts with that surface.
The virus surface and the environment: you can’t separate them out.”

More Than One Way to Skin a Cat… Or a Virus

Part of the reason the scientific community’s understanding of the SARS-CoV-2 virus
continues to evolve is because there are only a few techniques available to measure
the small amounts of virus particles required to infect a person as compared to other
types of biomolecules, such as proteins.

“We need to understand how viruses interact with surfaces with and without water present,
but the traditional ways we think of studying surface chemistry cannot detect these
low levels of virus,” Heldt said.

COVID-19 Testing Lab 

Since opening in April, Michigan Tech’s COVID-19 testing lab has run more than 3,500 samples, or the equivalent of testing 1% of the population
of Michigan’s Upper Peninsula.

Heldt and coauthors said their article provides a broad overview of different ways
researchers could learn more about these surface interactions on a chemical level.

Unlike the viruses that cause influenza, SARS-CoV-2 is mainly transmitted through
aerosols, or particles that travel through and stay suspended in the air when people
talk, sing, cough or sneeze.

The flu is transmitted by large droplets you breathe out, which fall to and stay infectious
on surfaces. Heldt said surfaces have not been ruled out as a mode of transmission,
but that the most common form of transition seems to be aerosol inhalation. “It’s
about how close you are to someone and for how long,” she said.

The Scientific Method 

In a short essay for the Michigan Tech Institute for Policy, Ethics, and Culture series “SARS-CoV-2:
What Kind of Crisis is This?” Caryn Heldt advocates for better science literacy and
explains why widespread public misunderstanding of the scientific method has led to
so much confusion about the virus.

Temperature and humidity in particular seem to have greater effects on the SARS-CoV-2
virus’ virility.

“For the first time, we highlight potential mechanisms of the novel SARS-CoV-2 surface
stability in various environmental conditions including temperature and relative humidity,”
said Aliakbar Hassanpouryouzband, a postdoctoral research associate at the University
of Edinburgh.

While viruses are typically more stable when it’s colder, which explains why flu season
hits during the winter, that doesn’t seem to be the case for the virus that causes
COVID-19. However, researchers can infer from what heat does to molecules — it increases
their energy, causing them to move and vibrate more quickly — that increased vibrations
of virus molecules causes them to explode and no longer be infectious.

When it comes to humidity, viruses need to bind some water to their surfaces. But
dehydrating a virus molecule isn’t a cut-and-dried solution — it can actually make
some molecules more stable.

Along with further research into the effects of humidity, temperature and other environmental
conditions, there’s a need to explore the effects of pH balance and protein casings
on the virus. The work to better understand the surface chemistry of SARS-CoV-2 will
help scientists around the world design vaccines for this pandemic and those of the

A diagram of illustrated Atomic Force Microscopy tips and the SARS-CoV-2 virus.
Atomic Force Microscopy tips can be negatively or positively charged to measure the
surface charge on the virus. Image Credit: Chem Journal-Cell Press 

“We hope that this article will assist experimental scientists worldwide in their
investigations for unravelling the molecular drivers implicated in this new coronavirus
transmission from the surfaces as well as in vaccine development and antiviral drug
design,” said Edris Joonaki, fluid properties expert at TÜV SÜD UK National Engineering


Michigan Technological University is a public research university, home to more than
7,000 students from 54 countries. Founded in 1885, the University offers more than
120 undergraduate and graduate degree programs in science and technology, engineering,
forestry, business and economics, health professions, humanities, mathematics, and
social sciences. Our campus in Michigan’s Upper Peninsula overlooks the Keweenaw Waterway
and is just a few miles from Lake Superior.

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